Fluorinated diselenide nanoparticles for radiosensitizing therapy of cancer

0557919 - ÚMCH 2023 RIV US eng J - Journal Article
Vetrík, Miroslav - Kučka, Jan - Kobera, Libor - Konefal, Rafal - Lobaz, Volodymyr - Pavlova, Ewa - Báječný, M. - Heizer, T. - Brus, Jiří - Šefc, L. - Pratx, G. - Hrubý, Martin
Fluorinated diselenide nanoparticles for radiosensitizing therapy of cancer.
Free Radical Biology and Medicine. Roč. 187, July (2022), s. 132-140. ISSN 0891-5849. E-ISSN 1873-4596
R&D Projects: GA MŠMT(CZ) LTC19032; GA ČR(CZ) GA21-01090S
Grant - others:AV ČR(CZ) DAAD-19-09; AV ČR(CZ) MSM200501801
Program: Bilaterální spolupráce; Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Research Infrastructure: Czech-BioImaging II - 90129
Institutional support: RVO:61389013
Keywords : diselenide * fluorosomes * self-assembly nanoparticles
OECD category: Polymer science
Impact factor: 7.4, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0891584922001988?via%3Dihub

Radiation resistance of cancer cells represents one of the major challenges in cancer treatment. The novel self-assembled fluoralkylated diselenide nanoparticles (fluorosomes) based on seleno-l-cystine (17FSe2) possess redox-active properties that autocatalytically decompose hydrogen peroxide (H2O2) and oxidize the intracellular glutathione (GSH) that results in regulation of cellular oxidative stress. Alkylfluorinated diselenide nanoparticles showed a significant cytotoxic and radiosensitizing effect on cancer cells. The EL-4 tumor-bearing C56BL/6 mice treated with 17FSe2 followed by fractionated radiation treatment (4 × 2Gy) completely suppressed tumor growth. Our results suggest that described diselenide system behaves as a potent radiosensitizer agent targeting tumor growth and preventing tumor recurrence.
Permanent Link: http://hdl.handle.net/11104/0332055