Covalent functionalization of Ti.sub.3./sub.C.sub.2./sub.T MXene flakes with Gd-DTPA complex for stable and biocompatible MRI contrast agent

0557728 - FZÚ 2023 RIV NL eng J - Journal Article
Neubertová, V. - Guselnikova, O. - Yamauchi, Y. - Olshtrem, A. - Rimpelová, S. - Čižmár, E. - Orendáč, M. - Duchoň, Jan - Volfová, Lenka - Lančok, Ján - Herynek, V. - Fitl, P. - Ulbrich, P. - Jelínek, L. - Schneider, P. - Kosek, J. - Postnikov, P. - Kolská, Z. - Švorčík, V. - Chertopalov, Sergii - Lyutakov, O.
Covalent functionalization of Ti₃C₂T MXene flakes with Gd-DTPA complex for stable and biocompatible MRI contrast agent.
Chemical Engineering Journal. Roč. 446, č. 2 (2022), č. článku 136939. ISSN 1385-8947. E-ISSN 1873-3212
R&D Projects: GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Research Infrastructure: CzechNanoLab - 90110
Institutional support: RVO:68378271
Keywords : MXene * surface chemistry * covalent functionalization * magnetic properties * MRI contrast agents * stability in bioliquids * cytotoxicity
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 15.1, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.cej.2022.136939

MXenes are an excellent candidate for medical applications, including diagnostic approaches such as positron emission tomography, computed tomography, and magnetic resonance imaging (MRI). However, the utilization of MXenes for bioimaging is restricted by their commonly diamagnetic nature. MXenes can be functionalized using ferromagnetic or paramagnetic compounds and nanoparticles to develop efficient bioimaging tools. In contrast to previously published approaches based on electrostatic interactions, covalent approaches could enhance MXene stability and prevent self-aggregation with degradation.
Permanent Link: http://hdl.handle.net/11104/0331656