Immunoengineering strategies to enhance vascularization and tissue regeneration

0557599 - FGÚ 2023 RIV NL eng J - Journal Article
Zárubová, Jana - Hasani-Sadrabadi, M. M. - Ardehali, R. - Li, S.
Immunoengineering strategies to enhance vascularization and tissue regeneration.
Advanced Drug Delivery Reviews. Roč. 184, May (2022), č. článku 114233. ISSN 0169-409X. E-ISSN 1872-8294
Institutional support: RVO:67985823
Keywords : neutrophils * macrophages * T cells * immunomodulation * cell delivery * extracellular vesicles * biomaterial * immune cell metabolism * stiffness * patterning
OECD category: Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
Impact factor: 16.1, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.addr.2022.114233

Immune cells have emerged as powerful regulators of regenerative as well as pathological processes. The vast majority of regenerative immunoengineering efforts have focused on macrophages, however, growing evidence suggests that other cells of both the innate and adaptive immune system are as important for successful revascularization and tissue repair. Moreover, spatiotemporal regulation of immune cells and their signaling have a significant impact on the regeneration speed and the extent of functional recovery. In this review, we summarize the contribution of different types of immune cells to the healing process and discuss ways to manipulate and control immune cells in favor of vascularization and tissue regeneration. In addition to cell delivery and cell-free therapies using extracellular vesicles, we discuss in situ strategies and engineering approaches to attract specific types of immune cells and modulate their phenotypes. This field is making advances to uncover the extraordinary potential of immune cells and their secretome in the regulation of vascularization and tissue remodeling. Understanding the principles of immunoregulation will help us design advanced immunoengineering platforms to harness their power for tissue regeneration.
Permanent Link: http://hdl.handle.net/11104/0331781