Bile Acids Transporters of Enterohepatic Circulation for Targeted Drug Delivery

0557588 - BFÚ 2023 RIV CH eng J - Journal Article
Durnik, R. - Šindlerová, Lenka - Babica, P. - Jurček, O.
Bile Acids Transporters of Enterohepatic Circulation for Targeted Drug Delivery.
Molecules. Roč. 27, č. 9 (2022), č. článku 2961. E-ISSN 1420-3049
Institutional support: RVO:68081707
Keywords : alpha-ost-beta * organic solute transporter * export pump bsep * farnesoid-x-receptor * vitamin-d-receptor * multidrug-resistance * nuclear receptor * cholesterol homeostasis * protective mechanism * hepatic transport * bile acid * bile salt * enterohepatic circulation
OECD category: Biochemistry and molecular biology
Impact factor: 4.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1420-3049/27/9/2961

Bile acids (BAs) are important steroidal molecules with a rapidly growing span of applications across a variety of fields such as supramolecular chemistry, pharmacy, and biomedicine. This work provides a systematic review on their transport processes within the enterohepatic circulation and related processes. The focus is laid on the description of specific or less-specific BA transport proteins and their localization. Initially, the reader is provided with essential information about BAs ' properties, their systemic flow, metabolism, and functions. Later, the transport processes are described in detail and schematically illustrated, moving step by step from the liver via bile ducts to the gallbladder, small intestine, and colon, this description is accompanied by descriptions of major proteins known to be involved in BA transport. Spillage of BAs into systemic circulation and urine excretion are also discussed. Finally, the review also points out some of the less-studied areas of the enterohepatic circulation, which can be crucial for the development of BA-related drugs, prodrugs, and drug carrier systems.
Permanent Link: https://hdl.handle.net/11104/0340698