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Deferoxamine derivatives as medicaments
- 1.0557146 - BTÚ 2022 RIV eng P - Patent Document
Truksa, Jaroslav - Werner, Lukáš - Štursa, Jan
Deferoxamine derivatives as medicaments.
2021. Owner: BIOTECHNOLOGICKÝ ÚSTAV AV ČR, v. v. i. SMART BRAIN, s.r.o. Date of the patent acceptance: 25.08.2021. Patent Number: EP 3655414
Institutional support: RVO:86652036
Keywords : Iron * Cancer * Mitochondria
OECD category: Biochemistry and molecular biology
https://worldwide.espacenet.com/patent/search/family/059363022/publication/EP3655414B1?q=pn%3DEP3655414B1
The deferoxamine derivatives of general formula I and pharmaceutically acceptable salts thereof, at least one of R1 and R2 is a substituent of formula II. The novel derivatives are particularly suitable as medicaments, preferably for the treatment of cancer. Pharmaceutical preparations of compounds of formula I and a metal, preferably gallium, are also provided resulting in even more active medicaments or contrast agents. Combinations with other agents, resulting in synergistic effects are provided.
Permanent Link: http://hdl.handle.net/11104/0331200
Number of the records: 1