Binding of Arsenic by Common Functional Groups: An Experimental and Quantum-Mechanical Study

0556524 - BFÚ 2023 RIV CH eng J - Journal Article
Chille, D. - Mollica-Nardo, V. - Giuffre, O. - Ponterio, R.C. - Saija, F. - Šponer, Jiří - Trusso, S. - Cassone, G. - Foti, C.
Binding of Arsenic by Common Functional Groups: An Experimental and Quantum-Mechanical Study.
Applied Sciences-Basel. Roč. 12, č. 6 (2022), č. článku 3210. E-ISSN 2076-3417
Institutional support: RVO:68081707
Keywords : speciation * elements * fluids * arsenic interactions * andO donor ligands * complex formation constants * quantum-mechanical calculations
OECD category: Physical chemistry
Impact factor: 2.7, year: 2022
Method of publishing: Open access
https://www.mdpi.com/2076-3417/12/6/3210

Arsenic is a well-known contaminant present in different environmental compartments and in human organs and tissues. Inorganic As(III) represents one of the most dangerous arsenic forms. Its toxicity is attributed to its great affinity with the thiol groups of proteins. Considering the simultaneous presence in all environmental compartments of other common functional groups, we here present a study aimed at evaluating their contribution to the As(III) complexation. As(III) interactions with four (from di- to hexa-) carboxylic acids, five (from mono- to penta-) amines, and four amino acids were evaluated via experimental methods and, in simplified systems, also by quantum-mechanical calculations. Data were analyzed also with respect to those previously reported for mixed thiol-carboxylic ligands to evaluate the contribution of each functional group (-SH,COOH, andNH2) toward the As(III) complexation. Formation constants of As(III) complex species were experimentally determined, and data were analyzed for each class of ligand. An empirical relationship was reported, taking into account the contribution of each functional group to the complexation process and allowing for a rough estimate of the stability of species in systems where As(III) and thiol, carboxylic, or amino groups are involved. Quantum-mechanical calculations allowed for the evaluation and the characterization of the main chelation reactions of As(III). The potential competitive effects of the investigated groups were evaluated using cysteine, a prototypical species possessing all the functional groups under investigation. Results confirm the higher binding capabilities of the thiol group under different circumstances, but also indicate the concrete possibility of the simultaneous binding of As(III) by the thiol and the carboxylic groups.
Permanent Link: https://hdl.handle.net/11104/0340443