Synthesis, characterization, cytotoxicity and DNA/BSA binding of two amino acid palladium(II) complexes derived from alanine and valine

0556291 - FZÚ 2023 RIV US eng J - Journal Article
Mohammadi, F. - Mansouri-Torshizi, H. - Saeidifar, M. - Dehghanian, E. - Skořepová, Eliška - Dušek, Michal - Abdi, K.
Synthesis, characterization, cytotoxicity and DNA/BSA binding of two amino acid palladium(II) complexes derived from alanine and valine.
Nucleosides Nucleotides & Nucleic Acids. Roč. 41, č. 1 (2022), s. 97-122. ISSN 1525-7770. E-ISSN 1532-2335
Institutional support: RVO:68378271
Keywords : palladium(II) complex * amino acid * cytotoxicity * binding * thermodynamic * mechanism * molecular docking
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 1.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1080/15257770.2021.2011914

Two novel palladium(II)–amino acid complexes, [Pd(Ala)2]·H2O (PA) and [Pd(Val)2].H2O (PV) (Ala = alanine, Val = valine) were synthesized and characterized through FTIR, UV/Vis, 1H-NMR spectroscopies, CHN analysis, X-ray crystallography and molar conductivity measurement. Furthermore, cytotoxicity of Pd(II) complexes against human leukemia cancer cell line, MOLT4 showed promising cancer cell death that were less than cisplatin. Moreover, the interaction of both the complexes with DNA and BSA was studied using UV–Vis absorption and emission spectroscopic techniques that demonstrated the bindin gs occurred via van der Waals forces and hydrogen bond.
Permanent Link: http://hdl.handle.net/11104/0330577