Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

0555981 - ÚMG 2023 RIV CH eng J - Journal Article
Vokurka, M. - Lacina, L. - Brabek, J. - Kolář, Michal - Ng, Y.Z. - Smetana Jr, K.
Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production.
International Journal of Molecular Sciences. Roč. 23, č. 2 (2022), č. článku 964. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) EF16_019/0000785; GA ČR(CZ) GA19-05048S
Institutional support: RVO:68378050
Keywords : cancer microenvironment * cancer ecosystem * cancer-associated fibroblast * il-6 * exosome
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1422-0067/23/2/964

Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affect the cancer cell differentiation status, and the migration and formation of metastases. This is achieved through the production of the extracellular matrix and numerous bioactive factors. IL-6 seems to play the central role in the communication of noncancerous and cancer cells in the tumour. This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts. Available data on the exosomal cargo, which can significantly intensify interactions in the tumour, are summarised. The role of exosomes as mediators of the dialogue between cancer cells and cancer-associated fibroblasts is discussed together with their therapeutic relevance. The functional unity of the paracrine- and exosome-mediated communication of cancer cells with the tumour microenvironment represented by CAFs is worthy of attention.
Permanent Link: http://hdl.handle.net/11104/0330884