Deferasirox pyridine solvate and its Cu(II) complex: Synthesis, crystal structure, Hirshfeld surface analysis, antimicrobial assays and antioxidant activity

0555827 - FZÚ 2023 RIV NL eng J - Journal Article
Zandvakili, T. - Fatemi, S.J. - Ebrahimipour, S.Y. - Ebrahimnejad, H. - Castro, J. - Dušek, Michal - Eigner, Václav
Deferasirox pyridine solvate and its Cu(II) complex: Synthesis, crystal structure, Hirshfeld surface analysis, antimicrobial assays and antioxidant activity.
Journal of Molecular Structure. Roč. 1249, Feb (2022), č. článku 131525. ISSN 0022-2860. E-ISSN 1872-8014
R&D Projects: GA ČR(CZ) GA18-10504S
Research Infrastructure: CzechNanoLab - 90110
Institutional support: RVO:68378271
Keywords : deferasirox pyridine solvate * FTIR * X-ray diffraction * crystal structure * antimicrobial activities
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 3.8, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.molstruc.2021.131525

Deferasirox pyridine solvate [(DFX)(py)] and its Cu(II) complex [Cu(DFX)(py)], (DFX = deferasirox, py = pyridine) were synthesized and characterized using several techniques such as elemental analysis, Fourier-transform infrared (FTIR), molar conductivity and vibrating sample magnetometer (VSM). In ad- dition, the structure of both compounds was determined using single-crystal X-ray diffraction method. Antimicrobial activities of the synthesized com- pounds were investigated against Staphylococcus aureus, Bacillus cereus, Escherichia coli , and Pseudomonas aeruginosa bacteria. Likewise, the antib iofilm activity of these compounds was investigated against S. au- reus and P. aeruginosa bacteria.
Permanent Link: http://hdl.handle.net/11104/0330282