Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

0555733 - ÚMG 2022 RIV US eng J - Journal Article
Woo, X. - Sedláček, Radislav - Chuang, J.H. … Total 64 authors
Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts.
Nature Genetics. Roč. 53, č. 1 (2021), s. 86-99. ISSN 1061-4036. E-ISSN 1546-1718
Institutional support: RVO:68378050
Keywords : tumor xenografts * mouse models * breast * heterogeneity * aberrations * signatures * evolution * cells * architecture * metastasis
OECD category: Oncology
Impact factor: 41.376, year: 2021
Method of publishing: Open access
https://www.nature.com/articles/s41588-020-00750-6

Analysis of copy number alterations in 1,451 patient-derived xenografts (PDXs) and matched patient tumor samples shows strong conservation from patient tumors through late-passage PDXs and a lack of systematic copy number evolution driven by the mouse host.
Permanent Link: http://hdl.handle.net/11104/0330189