Genes controlling skeletal muscle glucose uptake and their regulation by endurance and resistance exercise

0555719 - ÚMG 2023 RIV US eng J - Journal Article
Verbrugge, S. - Alhusen, J. - Kempin, S. - Pillon, N. - Rozman, Jan - Wackerhage, H. - Kleinert, M.
Genes controlling skeletal muscle glucose uptake and their regulation by endurance and resistance exercise.
Journal of Cellular Biochemistry. Roč. 123, č. 2 (2022), s. 202-214. ISSN 0730-2312. E-ISSN 1097-4644
R&D Projects: GA MŠMT(CZ) LM2018126
Institutional support: RVO:68378050
Keywords : type-2 diabetes-mellitus * insulin sensitivity * glycemic control * transgenic mice * overexpression * increases * protects * phosphorylation * disruption * metabolism * exercise metabolism * glucose uptake * insulin sensitivity * insulin signaling * resistance and endurance exercise * skeletal muscle
OECD category: Biochemistry and molecular biology
Impact factor: 4, year: 2022
Method of publishing: Open access
https://onlinelibrary.wiley.com/doi/10.1002/jcb.30179

Exercise improves the insulin sensitivity of glucose uptake in skeletal muscle. Due to that, exercise has become a cornerstone treatment for type 2 diabetes mellitus (T2DM). The mechanisms by which exercise improves skeletal muscle insulin sensitivity are, however, incompletely understood. We conducted a systematic review to identify all genes whose gain or loss of function alters skeletal muscle glucose uptake. We subsequently cross-referenced these genes with recently generated data sets on exercise-induced gene expression and signaling. Our search revealed 176 muscle glucose-uptake genes, meaning that their genetic manipulation altered glucose uptake in skeletal muscle. Notably, exercise regulates the expression or phosphorylation of more than 50% of the glucose-uptake genes or their protein products. This included many genes that previously have not been associated with exercise-induced insulin sensitivity. Interestingly, endurance and resistance exercise triggered some common but mostly unique changes in expression and phosphorylation of glucose-uptake genes or their protein products. Collectively, our work provides a resource of potentially new molecular effectors that play a role in the incompletely understood regulation of muscle insulin sensitivity by exercise.
Permanent Link: http://hdl.handle.net/11104/0330192