WNT5B in Physiology and Disease

0555638 - BFÚ 2022 RIV CH eng J - Journal Article
Suthon, S. - Perkins, R.J. - Bryja, Vítězslav - Miranda-Carboni, G. - Krum, S.
WNT5B in Physiology and Disease.
Frontiers in Cell and Developmental Biology. Roč. 09, MAY 4 2021 (2021), č. článku 667581. ISSN 2296-634X. E-ISSN 2296-634X
Institutional support: RVO:68081707
Keywords : epithelial-mesenchymal transition * squamous-cell carcinoma * f-box protein * signaling pathway * colon-cancer * stem-cells
OECD category: Cell biology
Impact factor: 6.081, year: 2021
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fcell.2021.667581/full

WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical beta-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers.
Permanent Link: http://hdl.handle.net/11104/0330092