Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP

0555402 - BFÚ 2022 RIV DE eng J - Journal Article
Wunnava, S. - Dirscherl, C. - Výravský, J. - Kovařík, Aleš - Matyášek, Roman - Šponer, Jiří - Braun, D. - Šponer, Judit E.
Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP.
Chemistry - A European Journal. Roč. 27, č. 70 (2021), s. 17581-17585. ISSN 0947-6539. E-ISSN 1521-3765
Institutional support: RVO:68081707
Keywords : polymerization * oligonucleotides * molecules * chemistry
OECD category: Organic chemistry
Impact factor: 5.020, year: 2021
Method of publishing: Open access
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202103672

The assembly of ancient informational polymers from nucleotide precursors is the central challenge of life's origin on our planet. Among the possible solutions, dry polymerization of 3',5'-cyclic guanosine monophosphate (3',5'-cGMP) has been proposed as a candidate to create oligonucleotides of 15-20 units in length. However, the reported sensitivity of the reaction to the presence of cations raised questions of whether this chemistry could be relevant in a geological context. The experiments in this study show that the presence of cations is not restrictive as long as the reaction is conducted in an acidic environment, in contrast to previous reports that suggested optimal conditions at pH 9.
Permanent Link: http://hdl.handle.net/11104/0329923