Number of the records: 1
Chiral secondary amino acids, their importance, and methods of analysis
- 1.0555383 - BC 2023 RIV AT eng J - Journal Article
Zahradníčková, Helena - Opekar, Stanislav - Řimnáčová, Lucie - Šimek, Petr - Moos, Martin
Chiral secondary amino acids, their importance, and methods of analysis.
Amino Acids. Roč. 54, č. 5 (2022), s. 687-719. ISSN 0939-4451. E-ISSN 1438-2199
Institutional support: RVO:60077344
Keywords : D- and L-secondary amino acids * imino acids * proline analogues
OECD category: Analytical chemistry
Impact factor: 3.5, year: 2022
Method of publishing: Limited access
https://link.springer.com/content/pdf/10.1007/s00726-022-03136-6.pdf
Naturally occurring secondary amino acids, with proline as the main representative, contain an alpha-imino group in a cycle that is typically four-, five-, and six-membered. The unique ring structure exhibits exceptional properties—conformational rigidity, chemical stability, and specific roles in protein structure and folding. Many proline analogues have been used as valuable compounds for the study of metabolism of both prokaryotic and eukaryotic cells and for the synthesis of compounds with desired biological, pharmaceutical, or industrial properties. The d-forms of secondary amino acids play different roles in living organisms than the l-forms. They have different metabolic pathways, biological, physiological, and pharmacological effects, they can be indicators of changes and also serve as biomarkers of diseases. In the scientific literature, the number of articles examining d-amino acids in biological samples is increasing. The review summarises information on the occurrence and importance of d- and l-secondary amino acids—azetidic acid, proline, hydroxyprolines, pipecolic, nipecotic, hydroxypipecolic acids and related peptides containing these d-AAs, as well as the main analytical methods (mostly chromatographic) used for their enantiomeric determination in different matrices (biological samples, plants, food, water, and soil).
Permanent Link: https://hdl.handle.net/11104/0338478
Number of the records: 1