Differences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta

0555132 - BC 2022 RIV GB eng J - Journal Article
Taggart-Murphy, L. - Alama-Bermejo, Gema - Dolan, B. - Takizawa, F. - Bartholomew, J.
Differences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta.
Developmental and Comparative Immunology. Roč. 114, JAN 2021 (2021), č. článku 103829. ISSN 0145-305X. E-ISSN 1879-0089
R&D Projects: GA ČR(CZ) GP14-28784P; GA ČR(CZ) GX19-28399X
Institutional support: RVO:60077344
Keywords : ceratomyxa-shasta * chinook salmon * myxosporean parasite * resistant chinook * gene-expression * host factors * river * tshawytscha * population * virulence * Salmonid * Cytokine * Immunoglobulin * Fish disease * Intestine
OECD category: Veterinary science
Impact factor: 3.605, year: 2021
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0145305X20303840?via%3Dihub

Two genotypes of the intestinal parasite Ceratonova shasta infect Oncorhynchus mykiss: genotype 0 results in a chronic infection with low mortality while genotype IIR causes disease with high mortality. We determined parasite load and the relative expression of six immune factors (IgT, IgM, IL-6, IL-8, IL-10, IFNG) in fish infected with either genotype over 29 days post-exposure. In genotype IIR infections the host responded with upregulation of inflammatory and regulatory cytokines. In contrast, genotype 0 infection did not elicit an inflammatory response and expression of IFNG and IL-10 was lower. Antibody expression was upregulated in both infections but appeared to have limited efficacy in the virulent genotype IIR infections. Histologically, in genotype 0 infections the parasite migrated through the tissue layers causing inflammation but minimal damage to the mucosal epithelium, which contrasts with the severe pathology found in genotype IIR infections.
Permanent Link: http://hdl.handle.net/11104/0329663