Immunomodulatory Effects ofAllium sativum L. and its Constituents against Viral Infections and Metabolic Diseases

0555095 - MBÚ 2023 RIV NL eng J - Journal Article
del Rayo Camacho-Corona, M. - Camacho-Morales, A. - Gongora-Rivera, F. - Escamilla-Garcia, E. - Luis Morales-Landa, J. - Andrade-Medina, M. - Fernando Herrera-Rodulfo, A. - Garcia-Juarez, M. - Garcia-Espinosa, P. - Stefani, Tommaso - Gonzalez-Barranco, P. - Carrillo-Tripp, M.
Immunomodulatory Effects ofAllium sativum L. and its Constituents against Viral Infections and Metabolic Diseases.
Current Topics in Medicinal Chemistry. Roč. 22, č. 2 (2022), s. 109-131. ISSN 1568-0266. E-ISSN 1873-4294
Institutional support: RVO:61388971
Keywords : garlic allium-sativum * s-allyl cysteine * fatty liver-disease * nf-kappa-b * in-vitro * z-ajoene * cancer cells * organosulfur compounds * cytokine expression * possible mechanism * Garlic * Antiviral agents * Immunomodulation agents * Chronic diseases * Coronavirus infection * Metabolic diseases
OECD category: Microbiology
Impact factor: 3.4, year: 2022
Method of publishing: Limited access
https://www.eurekaselect.com/article/119000

Background: Allium sativum L., or garlic, is one of the most studied plants worldwide within the field of traditional medicine. Current interests lie in the potential use of garlic as a preventive measure and adjuvant treatment for viral infections, e.g., SARS-CoV-2. Even though it cannot be presented as a single treatment, its beneficial effects are beyond doubt. The World Health Organization has deemed it an essential part of any balanced diet with immunomodulatory properties. Objective: The aim of the study was to review the literature on the effects of garlic compounds and preparations on immunomodulation and viral infection management, with emphasis on SARS-CoV-2. Methods: Exhaustive literature search has been carried out on electronic databases. Conclusion: Garlic is a fundamental part of a well-balanced diet which helps maintain general good health. The reported information regarding garlic's ability to beneficially modulate inflammation and the immune system is encouraging. Nonetheless, more efforts must be made to understand the actual medicinal properties and mechanisms of action of the compounds found in this plant to inhibit or diminish viral infections, particularly SARS-CoV-2. Based on our findings, we propose a series of innovative strategies to achieve such a challenge in the near future.
Permanent Link: http://hdl.handle.net/11104/0331373