Number of the records: 1
Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility
- 1.0554554 - ÚMG 2022 RIV NL eng J - Journal Article
Forejt, Jiří - Jansa, Petr - Parvanov, Emil
Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility.
Trends in Genetics. Roč. 37, č. 12 (2021), s. 1095-1108. ISSN 0168-9525. E-ISSN 1362-4555
R&D Projects: GA ČR GA20-04075S
Keywords : strand break formation * x-chromosome * reproductive isolation * meiotic recombination * consomic strains * sex-chromosomes * wild mice * mouse * speciation * evolution
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 11.821, year: 2021
Method of publishing: Limited access
https://www-cell-com.d360prx.biomed.cas.cz/trends/genetics/fulltext/S0168-9525(21)00164-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0168952521001645%3Fshowall%3Dtrue
Hybrid sterility is a critical step in the evolution of reproductive barriers between diverging taxa during the process of speciation. Recent studies of young subspecies of the house mouse revealed a multigenic nature and frequent polymorphism of hybrid sterility genes as well as the recurrent engagement of the meiosis-specific gene PR domain-containing 9 (Prdm9) and X-linked loci. Prdm9-controlled hybrid sterility is essentially chromosomal in nature, conditioned by the sequence divergence between subspecies. Depending on the Prdm9 interallelic interactions and the X-linked Hstx2 locus, the same homologs either regularly recombine and synapse, or show impaired DNA DSB repair, asynapsis, and early meiotic arrest. Thus, Prdm9-dependent hybrid sterility points to incompatibilities affecting meiotic recombination as a possible mechanism of reproductive isolation between (sub)species.
Permanent Link: http://hdl.handle.net/11104/0329262
Number of the records: 1