INFRAFRONTIER quality principles in systemic phenotyping

0554550 - ÚMG 2023 RIV US eng J - Journal Article
Ehlich, H. - Cater, H. - Flenniken, A.M. - Goncalves Da Cruz, I. - Mura, A. - Ntafis, V. - Raess, M. - Selloum, M. - Stoeger, C. - Suchanová, Šárka - Vuolteenaho, R. - Brown s, S.D.M. - Herault, Y. - Hinttala, R. - Hrabe de Angelis, M. - Kollias, G. - Kontoyiannis, D.L. - Malissen, B. - McKerlie, C. - Sedláček, Radislav - Wells, S. - Zarubica, A. - Rozman, Jan - Sorg, T.
INFRAFRONTIER quality principles in systemic phenotyping.
Mammalian Genome. Roč. 33, č. 1 (2022), s. 120-122. ISSN 0938-8990. E-ISSN 1432-1777
R&D Projects: GA MŠMT(CZ) LM2018126
Research Infrastructure: CCP II - 90126
Institutional support: RVO:68378050
Keywords : quality control * phenotyping * animal model * reproducibility * replicability * ethics
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 2.5, year: 2022
Method of publishing: Limited access
https://link.springer.com/article/10.1007/s00335-021-09892-2

Improving reproducibility and replicability in preclinical research is a widely discussed and pertinent topic, especially regarding ethical responsibility in animal research. INFRAFRONTIER, the European Research Infrastructure for the generation, phenotyping, archiving, and distribution of model mammalian genomes, is addressing this issue by developing internal quality principles for its different service areas, that provides a quality framework for its operational activities. This article introduces the INFRAFRONTIER Quality Principles in Systemic Phenotyping of genetically altered mouse models. A total of 11 key principles are included, ranging from general requirements for compliance with guidelines on animal testing, to the need for well-trained personnel and more specific standards such as the exchange of reference lines. Recently established requirements such as the provision of FAIR (Findable, Accessible, Interoperable, Reusable) data are also addressed. For each quality principle, we have outlined the specific context, requirements, further recommendations, and key references.
Permanent Link: http://hdl.handle.net/11104/0329526