Dysregulation of Microtubule Nucleating Proteins in Cancer Cells

0554549 - ÚMG 2022 RIV CH eng J - Journal Article
Dráber, Pavel - Dráberová, Eduarda
Dysregulation of Microtubule Nucleating Proteins in Cancer Cells.
Cancers (Basel). Roč. 13, č. 22 (2021), č. článku 5638. E-ISSN 2072-6694
R&D Projects: GA ČR(CZ) GA19-20716S; GA ČR GA21-30281S; GA MŠMT LTAUSA19118
Institutional support: RVO:68378050
Keywords : gamma-tubulin expression * beta-iii-tubulin * differential expression * centrosome aberrations * cellular-distribution * spindle organization * binding * actin * gene * localization * cancers * microtubule nucleation * gamma-tubulin complexes
OECD category: Oncology
Impact factor: 6.575, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2072-6694/13/22/5638

Simple Summary: The dysfunction of microtubule nucleation in cancer cells changes the overall cytoskeleton organization and cellular physiology. This review focuses on the dysregulation of the gamma-tubulin ring complex (gamma-TuRC) proteins that are essential for microtubule nucleation. Recent research on the high-resolution structure of gamma-TuRC has brought new insight into the microtubule nucleation mechanism. We discuss the effect of gamma-TuRC protein overexpression on cancer cell behavior and new drugs directed to gamma-tubulin that may offer a viable alternative to microtubule-targeting agents currently used in cancer chemotherapy.
Permanent Link: http://hdl.handle.net/11104/0329257