Evolution and diversification of the nuclear envelope

0554438 - BC 2022 RIV US eng J - Journal Article
Padilla-Mejia, N.E. - Makarov, A.A. - Barlow, L.D. - Butterfield, E. - Field, Mark Christian
Evolution and diversification of the nuclear envelope.
Nucleus. Roč. 12, č. 1 (2021), s. 21-41. ISSN 1949-1034. E-ISSN 1949-1042
EU Projects: Wellcome Trust(GB) 204697/Z/16/Z
Institutional support: RVO:60077344
Keywords : lamin b-receptor * multiple sequence alignment * transmembrane protein * comparative genomics * membrane-trafficking * diabetes-mellitus * tumor-suppressor * optic atrophy * ribosomal-rna * pore complex * Nuclear envelope * heterochromatin * lamina * proteome * evolution * eukaryogenesis
OECD category: Cell biology
Impact factor: 4.590, year: 2021
Method of publishing: Open access
https://www.tandfonline.com/doi/full/10.1080/19491034.2021.1874135

Eukaryotic cells arose similar to 1.5 billion years ago, with the endomembrane system a central feature, facilitating evolution of intracellular compartments. Endomembranes include the nuclear envelope (NE) dividing the cytoplasm and nucleoplasm. The NE possesses universal features: a double lipid bilayer membrane, nuclear pore complexes (NPCs), and continuity with the endoplasmic reticulum, indicating common evolutionary origin. However, levels of specialization between lineages remains unclear, despite distinct mechanisms underpinning various nuclear activities. Several distinct modes of molecular evolution facilitate organellar diversification and to understand which apply to the NE, we exploited proteomic datasets of purified nuclear envelopes from model systems for comparative analysis. We find enrichment of core nuclear functions amongst the widely conserved proteins to be less numerous than lineage-specific cohorts, but enriched in core nuclear functions. This, together with consideration of additional evidence, suggests that, despite a common origin, the NE has evolved as a highly diverse organelle with significant lineage-specific functionality.
Permanent Link: http://hdl.handle.net/11104/0329147