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Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition

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    0554307 - BC 2022 RIV AU eng J - Journal Article
    Mazanec, Hynek - Koník, P. - Gardian, Zdenko - Kuchta, Roman
    Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition.
    International Journal for Parasitology. Roč. 51, č. 5 (2021), s. 327-332. ISSN 0020-7519. E-ISSN 1879-0135
    R&D Projects: GA ČR(CZ) GX19-28399X; GA MŠMT(CZ) LM2015062
    Institutional support: RVO:60077344
    Keywords : Exosomes * Secretion * Proteins * Size exclusion chromatography * lc?ms * ms * Electron microscopy
    OECD category: Marine biology, freshwater biology, limnology
    Impact factor: 4.330, year: 2021
    Method of publishing: Limited access
    https://www.sciencedirect.com/science/article/pii/S0020751920303179?via%3Dihub

    We provided the first known evidence of the presence and release of extracellular vesicles in adults of important model tapeworm Hymenolepis diminuta. Two different subtypes have been observed on the surface of the worm and among the secretory products confirmed by several microscopical methods. Proteomic analysis revealed the presence of parasite-specific proteins as well as those of the host in purified extracellular vesicles. Among the protein cargo, we identified potential drug targets, vaccine candidates and H. diminuta antigens. Finally, the protein composition further revealed proteins participating in the endosomal complex required for transport-dependent biogenesis pathway.
    Permanent Link: http://hdl.handle.net/11104/0328941

     
     
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