Functional characterization of the insulin signaling pathway in the hard tick Ixodes ricinus

0554206 - BC 2022 RIV DE eng J - Journal Article
Kozelková, Tereza - Doležel, David - Grunclová, Lenka - Kučera, Matěj - Perner, Jan - Kopáček, Petr
Functional characterization of the insulin signaling pathway in the hard tick Ixodes ricinus.
Ticks and Tick-borne Diseases. Roč. 12, č. 4 (2021), č. článku 101694. ISSN 1877-959X. E-ISSN 1877-9603
R&D Projects: GA ČR(CZ) GA18-01832S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : rhipicephalus boophilus microplus * blood * synganglion * receptors * localization * metabolism * expression * proteins * insights * target * Tick * Ixodes ricinus * Insulin receptor * akt * tor * RNA interference
OECD category: Parasitology
Impact factor: 3.817, year: 2021
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1877959X21000479?via%3Dihub

Ticks are blood-feeding arachnids transmitting a variety of pathogens to humans and animals. A unique trait in tick physiology is their ability to engorge and digest large amounts of host blood, ensuring their high reproductive potential. Activation of the blood digestive machinery in the tick gut, as well as processes controlling maturation of ovaries, are triggered upon blood meal uptake by still largely unknown mechanisms. Sensing of the nutritional status in metazoan organisms is facilitated by the evolutionarily conserved Insulin Signaling Pathway (ISP) and the interlinked Target of Rapamycin (TOR) pathway. Recently, we have identified three components of these pathways in the hard tick Ixodes ricinus midgut transcriptome, namely a putative insulin receptor (InR), and the downstream intracellular serine/threonine kinases AKT and TOR.
Permanent Link: http://hdl.handle.net/11104/0328824