Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials

0554162 - ÚACH 2022 RIV GB eng J - Journal Article
El Anwar, Suzan - Pazderová, Lucia - Bavol, Dmytro - Bakardjiev, Mario - Růžičková, Z. - Horáček, O. - Fojt, Lukáš - Kučera, R. - Grüner, Bohumír
Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials.
Chemical Communications. Roč. 58, č. 15 (2022), s. 2572-2575. ISSN 1359-7345. E-ISSN 1364-548X
R&D Projects: GA ČR(CZ) GA19-04630S; GA ČR(CZ) GA21-14409S
Institutional support: RVO:61388980 ; RVO:68081707
Keywords : cosan
OECD category: Inorganic and nuclear chemistry; Biochemistry and molecular biology (BFU-R)
Impact factor: 4.9, year: 2022
Method of publishing: Limited access
https://doi.org/10.1039/D1CC06979A

We report the difunctional modification of an anionic cobalta bis(dicarbollide)(1(-)) cluster with a B(8,8')-oxygen bridging unit that provides structural rigidity and an organic alkylazide substituent(s) on the carbon atoms of the metallacarborane cage. These ions present a good binding motif for incorporation into organic molecules using Huisgen-Sharpless (2+3) cycloaddition reactions. In addition, the compounds are chiral, as verified by separation of enantiomers using HPLC on chiral stationary phases (CSPs) and provide a high electrochemical peak in the window located outside of typical signals of biomolecules.
Permanent Link: http://hdl.handle.net/11104/0328798


Research data: RCS Publishing, CCDC, CCDC