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5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-D]pyrimidines for treatment of lymphoma
- 1.0553600 - ÚEB 2022 RIV eng P - Patent Document
Havlíček, Libor - Šturc, Antonín - Řezníčková, Eva - Jorda, Radek - Kryštof, Vladimír - Strnad, Miroslav
5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-D]pyrimidines for treatment of lymphoma.
2021. Owner: Ústav experimentální botaniky AV ČR, v. v. i. - Univerzita Palackého v Olomouci. Date of the patent acceptance: 30.11.2021. Patent Number: US11186583
Institutional support: RVO:61389030
Keywords : cell cycle * cyclin-depedent kinases * inhibitors
OECD category: Organic chemistry
https://pdfpiw.uspto.gov/.piw?PageNum=0&docid=11186583
5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidine derivatives of formula I that are effective inhibitors of kinases and exhibit strong antiproliferative and proapoptotic properties on lymphoma cells. Derivatives in the treatment of blood hyperproliferative diseases, such as Non-Hodgkin lymphomas are also disclosed.
Permanent Link: http://hdl.handle.net/11104/0328358
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