SCF Ligases and Their Functions in Oogenesis and Embryogenesis-Summary of the Most Important Findings throughout the Animal Kingdom

0553580 - ÚŽFG 2023 RIV CH eng J - Journal Article
Kinterová, Veronika - Kaňka, Jiří - Bártková, Alexandra - Toralová, Tereza
SCF Ligases and Their Functions in Oogenesis and Embryogenesis-Summary of the Most Important Findings throughout the Animal Kingdom.
Cells. Roč. 11, č. 2 (2022), č. článku 234. E-ISSN 2073-4409
Institutional support: RVO:67985904
Keywords : ubiquitin-proteasome system * ubiquitin * SCF ligases
OECD category: Developmental biology
Impact factor: 6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/2073-4409/11/2/234

SCF-dependent proteolysis was first discovered via genetic screening of budding yeast almost 25 years ago. In recent years, more and more functions of SCF (Skp1-Cullin 1-F-box) ligases have been described, and we can expect the number of studies on this topic to increase. SCF ligases, which are E3 ubiquitin multi-protein enzymes, catalyse protein ubiquitination and thus allow protein degradation mediated by the 26S proteasome. They play a crucial role in the degradation of cell cycle regulators, regulation of the DNA repair and centrosome cycle and play an important role in several diseases. SCF ligases seem to be needed during all phases of development, from oocyte formation through fertilization, activation of the embryonic genome to embryo implantation. In this review, we summarize known data on SCF ligase-mediated degradation during oogenesis and embryogenesis. In particular, SCF beta TrCP and SCFSEL-10/FBXW7 are among the most important and best researched ligases during early development. SCF beta TrCP is crucial for the oogenesis of Xenopus and mouse and also in Xenopus and Drosophila embryogenesis. SCFSEL-10/FBXW7 participates in the degradation of several RNA-binding proteins and thereby affects the regulation of gene expression during the meiosis of C. elegans. Nevertheless, a large number of SCF ligases that are primarily involved in embryogenesis remain to be elucidated.
Permanent Link: http://hdl.handle.net/11104/0330622