Number of the records: 1
Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime
- 1.0553496 - MBÚ 2023 RIV GB eng J - Journal Article
Horvat, M. - Weilch, V. - Rädisch, Robert - Hecko, S. - Schiefer, A. - Rudroff, F. - Wilding, B. - Klempier, N. - Pátek, Miroslav - Martínková, Ludmila - Winkler, M.
Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime.
Catalysis Science &Technology. Roč. 12, č. 1 (2022), s. 62-66. ISSN 2044-4753. E-ISSN 2044-4761
R&D Projects: GA ČR(CZ) GF20-23532L
Institutional support: RVO:61388971
Keywords : nitrile synthesis * carboxylic acid reductase * aldoxime dehydratase * chemoenzymatic cascade
OECD category: Biochemistry and molecular biology
Impact factor: 5, year: 2022
Method of publishing: Open access
https://pubs.rsc.org/en/content/articlelanding/2022/CY/D1CY01694F
We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.
Permanent Link: http://hdl.handle.net/11104/0330484
Number of the records: 1