Nanocrystalline chloroxine possesses broad-spectrum antimicrobial activities and excellent skin tolerability in mice

0553047 - ÚMCH 2023 RIV GB eng J - Journal Article
Trousil, Jiří - Matějková, J. - Dai, Y.-S. - Urbánek, Tomáš - Šlouf, Miroslav - Škorič, M. - Nejedlý, Tomáš - Hrubý, Martin - Fang, J.-Y.
Nanocrystalline chloroxine possesses broad-spectrum antimicrobial activities and excellent skin tolerability in mice.
Nanomedicine. Roč. 17, č. 3 (2022), s. 137-149. ISSN 1743-5889. E-ISSN 1748-6963
R&D Projects: GA ČR(CZ) GA21-01090S
Grant - others:AV ČR(CZ) MSM200502101
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Keywords : dermal infections * dermal safety * nanomedicine
OECD category: Nano-materials (production and properties)
Impact factor: 5.5, year: 2022
Method of publishing: Limited access
https://www.futuremedicine.com/doi/epub/10.2217/nnm-2021-0323

Background: Antimicrobial submicrometer particles are being studied as promising interventions against a wide range of skin conditions, such as fungal or bacterial infections. Aims: To submicronize chloroxine, the crystalline compound 5,7-dichloro-8-hydroxyquinoline, by nanoprecipitation and characterize the resulting assemblies. Methods: The chloroxine particles were stabilized by a nonionic surfactant and were studied by a broth microdilution assay against 20 medically important bacteria and fungi. The intervention was studied using a murine model of skin irritation. Results & conclusion: Chloroxine nanoparticles with a diameter of 600–800 nm exhibit good tolerability in terms of skin irritation in vivo and good antimicrobial activity. Thus, the fabricated formulation shows great promise for interventions for both cutaneous infection control and prophylaxis.
Permanent Link: http://hdl.handle.net/11104/0328449