Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics

0552887 - ÚMCH 2023 RIV US eng J - Journal Article
Švec, Pavel - Petrov, O. V. - Lang, J. - Štěpnička, P. - Groborz, Ondřej - Dunlop, David - Blahut, J. - Kolouchová, Kristýna - Loukotová, Lenka - Sedláček, O. - Heizer, T. - Tošner, Z. - Šlouf, Miroslav - Beneš, Hynek - Hoogenboom, R. - Hrubý, Martin
Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics.
Macromolecules. Roč. 55, č. 2 (2022), s. 658-671. ISSN 0024-9297. E-ISSN 1520-5835
R&D Projects: GA MŠMT(CZ) LTC19032; GA MŠMT(CZ) LM2018133; GA ČR(CZ) GA19-01438S
Grant - others:AV ČR(CZ) StrategieAV21/6; AV ČR(CZ) StrategieAV21/10
Program: StrategieAV; StrategieAV
Research Infrastructure: EATRIS-CZ III - 90133
Institutional support: RVO:61389013 ; RVO:61388955
Keywords : fluorinated polymer * ferrocene * redox-responsive polymer
OECD category: Polymer science; Physical chemistry (UFCH-W)
Impact factor: 5.5, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.macromol.1c01723

Fluorine-19 magnetic resonance imaging (19F MRI) stands out as a powerful tool for noninvasive diagnostics. In particular, polymer-based 19F MRI tracers offer tunable physicochemical properties, including solubility and thermoresponsiveness, and enhanced 19F MRI performance. However, these tracers do not detectably respond to redox changes or do so in only one redox state, thereby preventing potential applications to reactive oxygen species (ROS) bioimaging. Herein, we report the first amphiphilic redox-responsive, poly(2-oxazoline)-based polymers bearing fluorinated ferrocene moieties. Their hydrophobicity and redox responsiveness were tailored by changing the monomer ratio and substitution pattern of the fluorinated ferrocene units. Converting the diamagnetic fluorinated ferrocene moieties into paramagnetic ferrocenium markedly changed the chemical shift and relaxation times of the 19F nuclei distinguishable by 19F MRI. In turn, the statistical–diblock copolymers formed nanoparticles that disassemble upon oxidation, with no toxicity to cultured cells. Therefore, these polymers may be used to release lipophilic drugs in ROS-rich malignancies.
Permanent Link: http://hdl.handle.net/11104/0330408