Non-thermal plasma and laser irradiation as cues that bias redox balance in cells

0552017 - FZÚ 2022 CH eng A - Abstract
Smolková, Barbora - Lunova, Mariia - Uzhytchak, Mariia - Frtús, Adam - Kubinová, Šárka - Dejneka, Alexandr - Lunov, Oleg
Non-thermal plasma and laser irradiation as cues that bias redox balance in cells.
Cancers (Basel). MDPI. Roč. 13, č. 18 (2021), s. 13-13. E-ISSN 2072-6694.
[Therapeutic ROS and Immunity in Cancer—The TRIC-21 Meeting. 15.07.2021-16.07.2021, Online]
Institutional support: RVO:68378271
Keywords : non-thermal plasma * laser irradiation * hepatic cancer cells
OECD category: Biophysics
https://www.mdpi.com/2072-6694/13/18/4549/htm

The emerging fields of non-thermal plasma (NTP) and low power lasers have shown considerable promise in various biomedical applications, including cancer therapy. However, understanding the molecular mechanisms procuring cellular responses remains incomplete. Indeed, the key to successful clinical transfer of any technology is a deep understanding of molecular mechanisms at the cell level. Here, we would like to focus on potential mechanisms of action of NTPs and lasers, and challenges related to their identification. Firstly, we deciphered the molecular mechanisms of NTP-triggered cancer cell death. High levels of Bcl-2 protein expression resulted in cancer cell resistance to oxidative stress mediated by plasma. We disclosed detailed mechanisms of NTP-mediated alteration of redox signaling in liver cancer cells.
Permanent Link: http://hdl.handle.net/11104/0327200