Adsorption/desorption behavior of hyaluronic acid fragments at charged hydrophobic surface

0551532 - BFÚ 2023 RIV GB eng J - Journal Article
Švecová, E. - Ostatná, Veronika - Fojt, Lukáš - Hermannová, M. - Velebný, V. - Ondreáš, F.
Adsorption/desorption behavior of hyaluronic acid fragments at charged hydrophobic surface.
Carbohydrate Polymers. Roč. 277, FEB 1 2022 (2022), č. článku 118831. ISSN 0144-8617. E-ISSN 1879-1344
Institutional support: RVO:68081707
Keywords : self-assembled monolayers * 2-dimensional condensation * titration * secondary * dna * Alternating current voltammetry
OECD category: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Impact factor: 11.2, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0144861721012182?via%3Dihub

This work reveals the growing potential of novel electrochemical methods that are applicable for polysaccharides. It was shown for the first time that the molecules of hyaluronic acid (HA) exhibit electrochemical response using phase-sensitive alternating current (AC) voltammetry in phase-out mode. Adsorption and desorption processes of HA fragments at a charged interface of mercury electrode were observed in buffered HA solutions. Electrostatic and hydrophobic manners of interactions were distinguished for native hyaluronan fragments in a wide electric potential range. The AC voltammetry response depended on the temperature, concentration, and length of HA chains. Results of this work open possibilities for further structural characterization of widely used HA fragments and understanding manners of interactions with charged hydrophobic surfaces that could be useful in the future for understanding HA interactions at biological levels.
Permanent Link: https://hdl.handle.net/11104/0336918