Plasmalogen-based liquid crystalline multiphase structures involving docosapentaenoyl derivatives inspired by biological cubic membranes

0551384 - FZÚ 2022 RIV CH eng J - Journal Article
Angelova, A. - Angelov, Borislav - Drechsler, M. - Bizien, T. - Gorshkova, Yu. E. - Deng, Y.
Plasmalogen-based liquid crystalline multiphase structures involving docosapentaenoyl derivatives inspired by biological cubic membranes.
Frontiers in Cell and Developmental Biology. Roč. 9, FEB (2021), č. článku 617984. ISSN 2296-634X. E-ISSN 2296-634X
R&D Projects: GA MŠMT EF15_003/0000447; GA MŠMT EF16_019/0000789
Grant - others:OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447; OP VVV - ADONIS(XE) CZ.02.1.01/0.0/0.0/16_019/0000789
Research Infrastructure: ELI Beamlines III - 90141
Institutional support: RVO:68378271
Keywords : docosapentaenoyl phospholipids * lipid cubic phase * inverted hexagonal phase * plasmalogen-loaded cubosomes * hexosomes * SAXS * cryo-TEM
OECD category: Polymer science
Impact factor: 6.081, year: 2021
Method of publishing: Open access

Structural properties of plasmenyl-glycerophospholipids (plasmalogens) have been scarcely studied for plasmalogens with long polyunsaturated fatty acid (PUFA) chains, despite of their significance for the organization and functions of the cellular membranes. Elaboration of supramolecular assemblies involving PUFA-chain plasmalogens in nanostructured mixtures with lyotropic lipids may accelerate the development of nanomedicines for certain severe pathologies (e.g., peroxisomal disorders, cardiometabolic impairments, and neurodegenerative Alzheimer's and Parkinson's diseases). Here, we investigate the spontaneous self-assembly of bioinspired, custom-produced docosapentaenoyl (DPA) plasmenyl (ether) and ester phospholipids in aqueous environment (pH 7) by synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM).
Permanent Link: http://hdl.handle.net/11104/0326800