Heterogeneous Associative Plasticity in the Auditory Cortex Induced by Fear Learning - Novel Insight Into the Classical Conditioning Paradigm

0551377 - ÚEM 2022 RIV CZ eng J - Journal Article
Zelenka, Ondřej - Novák, Ondřej - Brunová, Aneta - Syka, Josef
Heterogeneous Associative Plasticity in the Auditory Cortex Induced by Fear Learning - Novel Insight Into the Classical Conditioning Paradigm.
Physiological Research. Roč. 70, č. 3 (2021), s. 447-460. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA18-09692S
Institutional support: RVO:68378041
Keywords : auditory cortex * plasticity * fear conditioning * single-cell resolution * interneurons
OECD category: Neurosciences (including psychophysiology
Impact factor: 2.139, year: 2021
Method of publishing: Open access
https://www.biomed.cas.cz/physiolres/pdf/2021/70_447.pdf

We used two-photon calcium imaging with single-cell and cell-type resolution. Fear conditioning induced heterogeneous tuning shifts at single-cell level in the auditory cortex, with shifts both to CS+ frequency and to the control CS- stimulus frequency. We thus extend the view of simple expansion of CS+ tuned regions. Instead of conventional freezing reactions only, we observe selective orienting responses towards the conditioned stimuli. The orienting responses were often followed by escape behavior.


Permanent Link: http://hdl.handle.net/11104/0326788