Disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic in March-October 2020: An exploratory analysis

0550106 - MBÚ 2022 RIV US eng J - Journal Article
Modrák, Martin - Bürkner, P. C. - Sieger, T. - Slisz, T. - Vašáková, M. - Mesežnikov, G. - Casas-Mendez, L. F. - Vajter, J. - Táborský, J. - Kubricht, V. - Suk, D. - Hořejšek, J. - Jedlička, M. - Mifková, A. - Jaroš, A. - Kubiska, M. - Váchalová, J. - Šín, R. - Veverková, M. - Pospíšil, Z. - Vohryzková, J. - Pokrievková, R. - Hrušák, K. - Christozová, K. - Leos-Barajas, V. - Fišer, K. - Hyánek, T.
Disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic in March-October 2020: An exploratory analysis.
PLoS ONE. Roč. 16, 10 October (2021), č. článku e0245103. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA MŠMT(CZ) LM2018131
Institutional support: RVO:61388971
Keywords : Adult * Aged * COVID-19 * Czech Republic * Disease Progression * Hospitalization
OECD category: Infectious Diseases
Impact factor: 3.752, year: 2021
Method of publishing: Open access
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245103

We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested positive for SARS-CoV-2 during the early phases of the pandemic in March-October 2020. The dataset contains baseline patient characteristics, breathing support required, pharmacological treatment received and multiple markers on daily resolution. Patients in the dataset were treated with hydroxychloroquine (N = 108), azithromycin (N = 72), favipiravir (N = 9), convalescent plasma (N = 7), dexamethasone (N = 4) and remdesivir (N = 3), often in combination. To explore association between treatments and patient outcomes we performed multiverse analysis, observing how the conclusions change between defensible choices of statistical model, predictors included in the model and other analytical degrees of freedom. Weak evidence to constrain the potential efficacy of azithromycin and favipiravir can be extracted from the data. Additionally, we performed external validation of several proposed prognostic models for Covid-19 severity showing that they mostly perform unsatisfactorily on our dataset.
Permanent Link: http://hdl.handle.net/11104/0325956