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Telomerase-positive somatic tissues of honeybee queens (Apis mellifera) display no DNA replication

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    0549905 - BC 2022 RIV CH eng J - Journal Article
    Koubová, Justina - Čapková Frydrychová, Radmila
    Telomerase-positive somatic tissues of honeybee queens (Apis mellifera) display no DNA replication.
    Cytogenetic and Genome Research. Roč. 161, 8/9 (2021), s. 470-475. ISSN 1424-8581. E-ISSN 1424-859X
    R&D Projects: GA ČR(CZ) GA18-21200S
    Grant - others:AV ČR(CZ) StrategieAV21/9
    Program: StrategieAV
    Institutional support: RVO:60077344
    Keywords : telomerase * honeybees * aging
    OECD category: Genetics and heredity (medical genetics to be 3)
    Impact factor: 1.941, year: 2021
    Method of publishing: Limited access
    https://www.karger.com/Article/Abstract/518888

    Telomere biology is closely linked to the process of aging. The restoration of telomere length by maintaining telomerase activity in certain cell types of human adults allows for the proliferative capacity of the cells and preserves the regeneration potential of the tissue. The absence of telomerase,
    that leads to telomere attrition and irreversible cell cycle arrest in most somatic cells, acts as a protective mechanism against uncontrolled cancer growth. Nevertheless, there have been numerous studies indicating noncanonical functions of telomerase besides those involved in telomere
    lengthening. Eusocial insects serve as a great system for aging research. This is because eusocial reproductives, such as queens and kings, have a significantly extended lifespan compared to nonreproductive individuals of the same species. We report that the somatic tissues of honeybee queens (Apis mellifera) are associated with upregulated telomerase activity, however, this upregulation does not fully correlate with the rate of DNA replication in the tissues. This indicates a noncanonical role of telomerase in the somatic tissues of honeybee queens.
    Permanent Link: http://hdl.handle.net/11104/0326568

     
     
Number of the records: 1  

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