A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes

0549639 - MBÚ 2022 RIV DE eng J - Journal Article
Darnaud, M. - De Vadder, F. - Bogeat, P. - Boucinha, L. - Bulteau, A-L. - Bunescu, A. - Couturier, C. - Delgado, A. - Dugua, H. - Elie, C. - Mathieu, A. - Novotná, Tereza - Ouattara, D. A. - Planel, S. - Saliou, A. - Šrůtková, Dagmar - Yansouni, J. - Stecher, B. - Schwarzer, Martin - Leulier, F. - Tamellini, A.
A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes.
Nature Communications. Roč. 12, č. 1 (2021), č. článku 6686. E-ISSN 2041-1723
R&D Projects: GA ČR(CZ) GJ18-07015Y
Grant - others:European Molecular Biology Organization (EMBO)(CZ) EMBO Installation grant 2018
Institutional support: RVO:61388971
Keywords : germ-free * health * mice * colonization * maturation * diversity * responses * database * mucosal * growth
OECD category: Immunology
Impact factor: 17.694, year: 2021
Method of publishing: Open access
https://www.nature.com/articles/s41467-021-26963-9

Here, the authors develop and characterize a mouse microbiota composed of 15 strains representative of the intestinal microbiota found in C57BL/6J specific opportunistic- and pathogen-free (C57Bl/6J SOPF) mice and derive a new standardized gnotobiotic mouse model, called GM15, which recapitulates the phenotypes of SOPF or SPF animals in different animal facilities with improved reproducibility.
Permanent Link: http://hdl.handle.net/11104/0325597