Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study

0549074 - ÚI 2022 RIV CH eng J - Journal Article
Brož, J. - Campbell, M. D. - Urbanová, J. - Nunes, M. A. - Brunerová, L. - Rahelic, D. - Janíčková Žďárská, D. - Taniwall, A. - Brabec, Marek - Berka, V. - Michalec, J. - Polák, J.
Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study.
Nutrients. Roč. 13, č. 11 (2021), č. článku 4165. E-ISSN 2072-6643
Institutional support: RVO:67985807
Keywords : type 1 diabetes * exercise * hypoglycemia * insulin therapy * glycemic excursion * hypoglycemia treatment
OECD category: Statistics and probability
Impact factor: 6.706, year: 2021
Method of publishing: Open access
http://dx.doi.org/10.3390/nu13114165

The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min−1 (minimum: 0.07, maximum: 0.17 mmol/L·min−1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min−1 (minimum: 0.06, maximum: 0.19 mmol/L·min−1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.
Permanent Link: http://hdl.handle.net/11104/0325100