Miro proteins connect mitochondrial function and intercellular transport

0549057 - BTÚ 2022 RIV GB eng J - Journal Article
Nahácka, Zuzana - Zobalová, Renata - Dubišová, Maria - Rohlena, Jakub - Neužil, Jiří
Miro proteins connect mitochondrial function and intercellular transport.
Critical Reviews in Biochemistry and Molecular Biology and CRC Critical Reviews in Biochemistry. Roč. 56, č. 4 (2021), s. 401-425. ISSN 1040-9238. E-ISSN 1549-7798
R&D Projects: GA ČR(CZ) GA20-05942S; GA ČR(CZ) GX21-04607X; GA MZd(CZ) NV17-30138A; GA ČR GA19-20553S; GA ČR(CZ) GA20-18513S
Institutional support: RVO:86652036
Keywords : Mitochondria * mitophagy * endoplasmic reticulum
OECD category: Biochemistry and molecular biology
Impact factor: 8.697, year: 2021
Method of publishing: Limited access
https://www.tandfonline.com/doi/full/10.1080/10409238.2021.1925216?scroll=top&needAccess=true

Mitochondria are organelles present in most eukaryotic cells, where they play major and multifaceted roles. The classical notion of the main mitochondrial function as the powerhouse of the cell per se has been complemented by recent discoveries pointing to mitochondria as organelles affecting a number of other auxiliary processes. They go beyond the classical energy provision via acting as a relay point of many catabolic and anabolic processes, to signaling pathways critically affecting cell growth by their implication in de novo pyrimidine synthesis. These additional roles further underscore the importance of mitochondrial homeostasis in various tissues, where its deregulation promotes a number of pathologies. While it has long been known that mitochondria can move within a cell to sites where they are needed, recent research has uncovered that mitochondria can also move between cells. While this intriguing field of research is only emerging, it is clear that mobilization of mitochondria requires a complex apparatus that critically involves mitochondrial proteins of the Miro family, whose role goes beyond the mitochondrial transfer, as will be covered in this review.
Permanent Link: http://hdl.handle.net/11104/0325087