Carbon-based nanomaterials increase reactivity of primary monocytes towards various bacteria and modulate their differentiation into macrophages

0548780 - FZÚ 2022 RIV CH eng J - Journal Article
Švadláková, T. - Koláčková, M. - Vaňková, R. - Karakale, R. - Málková, A. - Kulich, P. - Hubatka, F. - Turanek-Knotigová, P. - Kratochvílová, Irena - Raška, M. - Krejsek, J. - Turánek, Jaroslav
Carbon-based nanomaterials increase reactivity of primary monocytes towards various bacteria and modulate their differentiation into macrophages.
Nanomaterials. Roč. 11, č. 10 (2021), č. článku 2510. E-ISSN 2079-4991
R&D Projects: GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : graphene * carbon nanotubes * cytotoxicity
OECD category: Biophysics
Impact factor: 5.719, year: 2021
Method of publishing: Open access

The evaluation of carbon-based nanomaterials’ (C-BNMs’) interactions with the immune system, notably their ability to cause inflammation, is a critical step in C-BNM health risk assessment. Particular attention should be given to those C-BNMs that do not cause direct cytotoxicity or inflammation on their own. However, the intracellular presence of these non-biodegradable nanomaterials could dysregulate additional cell functions. This is even more crucial in the case of phagocytes, which are the main mediators of defensive inflammation towards pathogens. Hence, our study was focused on multi-walled carbon nanotubes (MWCNTs) and two different types of graphene platelets (GPs) and whether their intracellular presence modulates a proinflammatory response from human primary monocytes towards common pathogens.
Permanent Link: http://hdl.handle.net/11104/0324954