The Influence of High and Low Negative Pressure Liposuction and Various Harvesting Techniques on the Viability and Function of Harvested Cells-a Systematic Review of Animal and Human Studies

0548716 - FGÚ 2022 RIV US eng J - Journal Article
Molitor, M. - Trávníčková, Martina - Měšťák, O. - Christodoulou, P. - Sedlář, Antonín - Bačáková, Lucie - Lucchina, S.
The Influence of High and Low Negative Pressure Liposuction and Various Harvesting Techniques on the Viability and Function of Harvested Cells-a Systematic Review of Animal and Human Studies.
Aesthetic Plastic Surgery. Roč. 45, č. 5 (2021), s. 2379-2394. ISSN 0364-216X. E-ISSN 1432-5241
R&D Projects: GA MZd(CZ) NU20-08-00208; GA MŠMT(CZ) LQ1604
Institutional support: RVO:67985823
Keywords : adipocyte * ADSC * negative pressure * liposuction * fat grafting
OECD category: Biomaterials (as related to medical implants, devices, sensors)
Impact factor: 2.708, year: 2021
Method of publishing: Limited access
https://doi.org/10.1007/s00266-021-02249-9

Background An understanding of fat grafting methodology, techniques and patient-related factors is crucial when considering fat grafting. Multiple factors can influence the success of a fat graft and consequently the outcome of the procedure. The aim of this systematic review is to elucidate the influence of negative pressure and various techniques of fat harvesting on the viability and function of cells, particularly adipocytes and adipose-derived stem cells. Methods We conducted a literature search from 1975 to 2020 using the PubMed bibliography, ScienceDirect, SCOPUS and the Google Scholar databases which produced 168,628 articles on the first pass. After applying all the exclusion criteria by two independent reviewers, we were left with 21 articles (level IV of Oxford Centre for Evidence-Based Studies and Grade C of Grade Practice Recommendation from the American Society of Plastic Surgeons) on which this review is based. Results From 11 studies focused on different negative pressures, no one found using high negative pressure advantageous. Summarising 13 studies focused on various harvesting techniques (excision, syringe, and pump-machine), most often equal results were reported, followed by excision being better than either syringe or liposuction. Conclusion From our systematic review, we can conclude that the low negative pressure seems to yield better results and that the excision seems to be the most sparing method for fat graft harvesting. However, we have to point out that this conclusion is based on a very limited number of statistically challengeable articles and we recommend well-conducted further research.
Permanent Link: http://hdl.handle.net/11104/0324764