Polysubstituted pyrimidines inhibiting the formation of prostaglandin E2, a method of production thereof and use thereof

0547954 - ÚOCHB 2022 RIV eng P - Patent Document
Kolman, Viktor - Kalčic, Filip - Janeba, Zlatko - Zídek, Zdeněk
Polysubstituted pyrimidines inhibiting the formation of prostaglandin E2, a method of production thereof and use thereof.
2021. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Ústav experimentální medicíny AV ČR, v. v. i. Date of the patent acceptance: 27.10.2021. Patent Number: EP3630730
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidines * anti-inflammatory * prostaglandin E2 synthase
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=EP&NR=3630730B1&KC=B1&FT=D&ND=4&date=20211027&DB=&locale=en_EP

The invention describes the pyrimidine-based compounds of the general formula I. Described compounds lower the production of the prostaglandin E2. In concentrations lowering production of this factor by 50%, these compounds have no negative effect on the cell viability and they are not cytotoxic. Furthermore, the method of production of the compounds of the general formula I is provided. A pharmaceutical composition comprising the polysubstituted pyrimidines according to the invention and the use of these compounds for the treatment of the inflammatory diseases are also provided.
Permanent Link: http://hdl.handle.net/11104/0324097