Editorial: Employing Experimental Gnotobiotic Models to Decipher the Host-Microbiota Cross-Talk in Health and Disease

0547573 - MBÚ 2022 RIV CH eng J - Journal Article
Schwarzer, Martin - Tlaskalová-Hogenová, Helena - Leulier, F. - Schabussova, I.
Editorial: Employing Experimental Gnotobiotic Models to Decipher the Host-Microbiota Cross-Talk in Health and Disease.
Frontiers in Immunology. Roč. 12, AUG 3 2021 (2021), č. článku 729052. ISSN 1664-3224. E-ISSN 1664-3224
R&D Projects: GA ČR(CZ) GJ18-07015Y; GA MZd(CZ) NV19-03-00179
Grant - others:European Molecular Biology Organization (EMBO)(CZ) EMBO Installation grant 2018
Institutional support: RVO:61388971
Keywords : germ-free * germ-free * host-bacteria interactions * microbiota * gnotobiology * immune system
OECD category: Immunology
Impact factor: 8.787, year: 2021
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fimmu.2021.729052/full

the daunting task of keeping their exposed surfaces germ-free (GF), they have developed close symbiotic relationships. Mucosal surfaces are associated with specific microbial communities that influence various aspects of host physiology and, most importantly, the development and finetuning of the immune system. In the last decade, we have witnessed a renewed interest in understanding the role of the microbiota for the homeostasis and disease. This has fostered the development of sophisticated multidisciplinary technologies that enable compositional and functional analysis of the microbiome. The most diverse and numerous microbial communities are found in the gastrointestinal tract. Alterations in the gut microbiome and/or disruptions of the cross-talk between host and microbiota has been linked to immune-mediated diseases such as allergies and autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis and diabetes. The aforementioned complexity of the gut microbial ecosystem currently complicates the understanding of the microbiota-host cross-talk, with
descriptive reports predominating over mechanistic studies. However, powerful tools for studying host-microbe interactions are germ-free (GF) and gnotobiotic animal models. Although historically mostly rodents and piglets have been used, new vertebrate models, for example fish, and invertabrate models such as Drosophila have successfully been developed in recent years

Permanent Link: http://hdl.handle.net/11104/0323785