Zn–0.8Mg–0.2Sr (wt.%) absorbable screws—an in-vivo biocompatibility and degradation pilot study on a rabbit model

0546336 - FZÚ 2022 RIV CH eng J - Journal Article
Klíma, K. - Ulmann, D. - Bartoš, M. - Španko, M. - Dušková, J. - Vrbová, R. - Pinc, Jan - Kubásek, J. - Ulmannová, T. - Foltán, R. - Brizman, E. - Drahoš, M. - Beňo, M. - Čapek, Jaroslav
Zn–0.8Mg–0.2Sr (wt.%) absorbable screws—an in-vivo biocompatibility and degradation pilot study on a rabbit model.
Materials. Roč. 14, č. 12 (2021), č. článku 3271. E-ISSN 1996-1944
R&D Projects: GA MŠMT LM2018110; GA MŠMT(CZ) EF16_019/0000760; GA ČR(CZ) GA18-06110S
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : bioabsorbable metals * in-vivo biocompatibility * magnesium * zinc * strontium * toxicity * biocompatibility * systemic reactions * alloy accumulation
OECD category: Materials engineering
Impact factor: 3.748, year: 2021
Method of publishing: Open access

In this study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical assessment, microCT, histological examination of implants, analyses of the adjacent bone, and assessment of zinc, magnesium, and strontium in vital organs (liver, kidneys, brain). Only negligible changes of the implant volume and area were observed. The degradation was not connected with gas evolution. The screws were fibrointegrated, partially osseointegrated histologically. We observed no inflammatory reaction or bone resorption. Periosteal apposition and formation of new bone with a regular structure were frequently observed near the implant surface. The histological evaluation of the liver, kidneys, and brain showed no toxic changes. The alloy was safe, biocompatible, and well-tolerated.
Permanent Link: http://hdl.handle.net/11104/0322890