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Synthesis of [13C6]-ibrutinib
- 1.0546208 - ÚOCHB 2022 RIV GB eng J - Journal Article
Kriegelstein, Michal - Hroch, M. - Marek, Aleš
Synthesis of [13C6]-ibrutinib.
Journal of Labelled Compounds and Radiopharmaceuticals. Roč. 64, č. 13 (2021), s. 500-512. ISSN 0362-4803. E-ISSN 1099-1344
Institutional support: RVO:61388963
Keywords : carbon-13 * cost-effective synthesis * stable isotope labeling * [13C6]-ibrutinib
OECD category: Analytical chemistry
Impact factor: 1.949, year: 2021
Method of publishing: Limited access
https://doi.org/10.1002/jlcr.3944
Convenient and straightforward synthesis of ibrutinib labeled by carbon-13 isotope is reported. Isotopically labeled building block is introduced in the last step of reaction sequence affording sufficient isolated yield (7%) of [13C6]-ibrutinib calculated towards starting commercially available [13C6]-bromobenzene.
Permanent Link: http://hdl.handle.net/11104/0322756
Number of the records: 1