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Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy
- 1.0545888 - ÚEB 2022 RIV GB eng J - Journal Article
Özdemir, Zülal - Yang, M. - Kim, G. - Bildziukevich, Uladzimir - Šaman, David - Li, X. - Yoon, J.-N. - Wimmer, Zdeněk
Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy.
Dyes and Pigments. Roč. 190, JUN (2021), č. článku 109307. ISSN 0143-7208. E-ISSN 1873-3743
R&D Projects: GA MPO(CZ) FV10599; GA MPO(CZ) FV30300
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Photodynamic therapy * Redox-responsive * ros * Self-assembled nanoparticles * Tumour targeting
OECD category: Organic chemistry
Impact factor: 5.122, year: 2021
Method of publishing: Open access
http://doi.org/10.1016/j.dyepig.2021.109307
The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT).
Permanent Link: http://hdl.handle.net/11104/0322514
File Download Size Commentary Version Access 2021_Ozdemir_Dyes and Pigments_109307.pdf 1 5.9 MB Other open-access
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