Direct comparison of analogous amphiphilic gradient and block polyoxazolines

0545562 - ÚMCH 2022 RIV US eng J - Journal Article
Loukotová, Lenka - Švec, Pavel - Groborz, Ondřej - Heizer, T. - Beneš, Hynek - Raabová, Helena - Bělinová, T. - Herynek, V. - Hrubý, Martin
Direct comparison of analogous amphiphilic gradient and block polyoxazolines.
Macromolecules. Roč. 54, č. 17 (2021), s. 8182-8194. ISSN 0024-9297. E-ISSN 1520-5835
R&D Projects: GA ČR(CZ) GA19-01602S; GA MŠMT(CZ) LTC19032; GA MŠMT(CZ) LM2015062; GA MŠMT(CZ) LM2018129; GA MŠMT(CZ) EF16_013/0001775
Grant - others:AV ČR(CZ) FWO-19-03
Program: Bilaterální spolupráce
Research Infrastructure: Czech-BioImaging - 90062; Czech-BioImaging II - 90129
Institutional support: RVO:61389013 ; RVO:68378050
Keywords : poly-2-phenyl-2-oxazoline * gradient polymer * polymerization kinetics
OECD category: Polymer science; Biochemistry and molecular biology (UMG-J)
Impact factor: 6.057, year: 2021
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.macromol.0c02674

Both gradient and block copolymers can be used as drug delivery systems, but their relative (dis)advantages remain unknown. Thus, we directly compared analogous amphiphilic gradient and block polyoxazolines for their physicochemical properties and potential as building components of nanodrugs. For this purpose, we prepared a library of 18 polymers with varying ratios of monomeric units, using 2-methyl-2-oxazoline (MeOx) as a hydrophilic monomer and 2-phenyl-2-oxazoline (PhOx), 2-(4-butylphenyl)-2-oxazoline (BuPhOx), or 2-(4-butoxyphenyl)-2-oxazoline (BuOPhOx) as a hydrophobic monomer, and determined their homo/heteropolymerization kinetics. Our results showed that gradient copolymers had broader glass transition intervals and formed nanoparticles several times smaller and more compact than the corresponding block analogs. In particular, PMeOx70-grad-PhOx30 and PMeOx70-grad-BuPhOx30 exhibited a significantly higher drug loading capacity and entrapment efficiency than their corresponding block analogs. Notwithstanding these differences, all polymers were cyto- and hemocompatible in vitro. Therefore, analogous gradient and block copolymers may be alternatively used for specific biomedical applications.
Permanent Link: http://hdl.handle.net/11104/0322846