Co-adjuvant nanoparticles for radiotherapy treatments of oncological diseases

0545253 - FZÚ 2022 RIV CH eng J - Journal Article
Crapanzano, L. - Secchi, V. - Villa, Irene
Co-adjuvant nanoparticles for radiotherapy treatments of oncological diseases.
Applied Sciences-Basel. Roč. 11, č. 15 (2021), č. článku 7073. E-ISSN 2076-3417
Institutional support: RVO:68378271
Keywords : nanoparticles * scintillation * ionizing energy deposition * radiotherapy * photodynamic therapy * singlet oxygen
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 2.838, year: 2021
Method of publishing: Open access

In this review, we describe the most recent methods exploiting heavy nanoparticles and hybrid nanomaterials aiming at improving the traditional X-rays-based treatments. High-Z nanoparticles are proposed as radiosensitizers due to their ability to stop the ionizing radiation and to increase the locally delivered therapeutic dose. Other nanoparticles working as catalysts can generate reactive oxygen species upon X-rays exposure. Thanks to their high toxicity and reactivity, these species promote DNA cancer cells damage and apoptosis. Hybrid nanoparticles, composed by scintillators coupled to organic molecules, are suitable in X-rays activated photodynamic therapy. This work highlights the roles played by the diverse nanoparticles, upon ionizing radiation irradiation, according to their physico-chemical properties, surface functionalization, and targeting strategies.
Permanent Link: http://hdl.handle.net/11104/0322003