Liver organoids: recent developments, limitations and potential

0545144 - FZÚ 2022 RIV CH eng J - Journal Article
Harrison, S.P. - Baumgarten, S.F. - Verma, R. - Lunov, Oleg - Dejneka, Alexandr - Sullivan, G.J.
Liver organoids: recent developments, limitations and potential.
Frontiers in Medicine. Roč. 8, May (2021), č. článku 574047. E-ISSN 2296-858X
R&D Projects: GA MŠMT LTC19040
Institutional support: RVO:68378271
Keywords : liver Organoids * limitations and potential * microscopy * liver * induced pluripotent stem cells (iPSCs)
OECD category: Cell biology
Impact factor: 5.058, year: 2021
Method of publishing: Open access

Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to investigate development, toxicity, as well as genetic and infectious disease in ways currently limited by the availability of primary tissue. With the added advantage of patient specificity, which can play a role in all of these areas. Many iPSC differentiation protocols focus on 3 dimensional (3D) or organotypic differentiation, as these offer the advantage of more closely mimicking in vivo systems including the formation of tissue like architecture and interactions/crosstalk between different cell types. Ultimately such models have the potential to be used clinically and either with or more aptly, in place of animal models. Along with the development of organotypic and micro-tissue models, there will be a need to co-develop imaging technologies to enable their visualization.

Permanent Link: http://hdl.handle.net/11104/0321893