Enzymatic detoxification of cyanide using cyanide hydratases

0545117 - MBÚ 2022 RIV CZ eng K - Conference Paper (Czech conference)
Sedova, Anastasia - Rucká, Lenka - Glozlová, Michaela - Novotný, Petr - Martínková, Ludmila - Bojarová, Pavla
Enzymatic detoxification of cyanide using cyanide hydratases.
New Approaches to State Security Assurance. Brno: Universita obrany v Brně, 2021, s. 223-227. ISBN 978-80-7582-104-1.
[15th Annual Doctoral Conference proceedings. Brno (CZ), 11.02.2021]
R&D Projects: GA ČR(CZ) GA18-00184S
Institutional support: RVO:61388971
Keywords : free cyanide * cyanide hydratase * cyanide spills * cyanide waste
OECD category: Biochemistry and molecular biology

Cyanide, a strong chelator of metals in vital enzymes and proteins, is very toxic for most living organisms. Wastewaters from the mining, metallurgical and chemical industries contain significant concentrations of free cyanide. Though it can be largely eliminated by physicochemical methods, these processes may in turn lead to the formation of other waste. In addition, no effective methods have been found to neutralize cyanide spills coming from industrial accidents. The use of enzymes to remove cyanide is an attractive alternative, which is environmentally friendly and applicable to high cyanide concentrations. Cyanide hydratases (CynHs) are of considerable interest for the decomposition of hazardous cyanide wastes. Here we investigate the biochemical properties of new CynHs from Stereum hirsutum and Exidia glandulosa, it is of fundamental importance to preserve the enzyme activity at alkaline pH as cyanide waste is stored under these conditions.
Permanent Link: http://hdl.handle.net/11104/0321874