Hormones, regulators and viruses

0545044 - ÚOCHB 2022 RIV US eng M - Monography Chapter
Hejtmánková, A. - Váňová, J. - Španielová, Hana
Cell-penetrating peptides in the intracellular delivery of viral nanoparticles.
Hormones, regulators and viruses. Cambridge: Academic Press, 2021 - (Litwack, G.), s. 47-76. Vitamins and hormones, 117. ISBN 978-0-323-90731-6
Institutional support: RVO:61388963
Keywords : cell-penetrating peptides * intracellular delivery * protein transduction domain * TAT * viral nanoparticles * viroporins
OECD category: Biochemistry and molecular biology
https://doi.org/10.1016/bs.vh.2021.06.010

Cell-penetrating peptides (CPPs) are a promising tool for the intracellular delivery of cargo. Due to their ability to cross membranes while also cotransporting various cargoes, they offer great potential for biomedical applications. Several CPPs have been derived from viral proteins with natural roles in the viral replication cycle that require them to breach or fuse to cellular membranes. Additionally, the ability of viruses to cross membranes makes viruses and virus-based particles a convenient model for research on nanoparticle delivery and nanoparticle-mediated gene therapy. In this chapter, we aim to characterize CPPs derived from both structural and nonstructural viral proteins. Their function as enhancers of viral infection and transduction by viral nanoparticles as well as the main features of viral CPPs employed in intracellular cargo delivery are summarized to emphasize their potential use in nanomedicine.
Permanent Link: http://hdl.handle.net/11104/0321822