CD8(+) Tregs revisited: A heterogeneous population with different phenotypes and properties

0544971 - ÚMG 2022 RIV DE eng J - Journal Article
Niederlová, Veronika - Tsyklauri, Oksana - Chadimová, Tereza - Štěpánek, Ondřej
CD8(+) Tregs revisited: A heterogeneous population with different phenotypes and properties.
European Journal of Immunology. Roč. 51, č. 3 (2021), s. 512-530. ISSN 0014-2980. E-ISSN 1521-4141
R&D Projects: GA ČR GJ19-03435Y
Institutional support: RVO:68378050
Keywords : Autoimmunity * CD8 T cells * Homeostasis * Regulatory T cells * Tolerance
OECD category: Immunology
Impact factor: 6.688, year: 2021
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/10.1002/eji.202048614

Regulatory T cells (Tregs) play a key role in the peripheral self-tolerance and preventing autoimmunity. While classical CD4(+) Foxp3(+) Tregs are well established, their CD8(+) counterparts are still controversial in many aspects including their phenotypic identity and their mechanisms of suppression. Because of these controversies and because of only a limited number of studies documenting the immunoregulatory function of CD8(+) Tregs in vivo, the concept of CD8(+) Tregs is still not unanimously accepted. We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8(+) Tregs by focusing on the characterization of individual CD8(+) T-cell subsets with proposed regulatory capacity separately. Therefore, we review the phenotype and function of CD8(+) FOXP3(+) T cells, CD8(+) CD122(+) T cells, CD8(+) CD28(low/-) T cells, CD8(+) CD45RC(low) T cells, T cells expressing CD8 alpha alpha homodimer and Qa-1-restricted CD8(+) T cells to show whether there is sufficient evidence to establish these subsets as bona fide Tregs. Based on the intrinsic ability of CD8(+) Treg subsets to promote immune tolerance in animal models, we elaborate on their potential use in clinics.
Permanent Link: http://hdl.handle.net/11104/0321758